| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide use of dimeric oligocation derivatives for preparing medicaments to prevent or treat inflammatory or neurodegenerative disease, and compounds, pharmaceutical compositions for use of the same. <P>SOLUTION: There are provided low molecular weight apoE mimetic agents suitable for preparing medicaments to treat autoimmune, inflammatory or neurodegenerative disease. The agents are represented by general formula (I): (X)<SB POS="POST">a</SB>-L-(X)<SB POS="POST">b</SB>, [wherein each X is a (potentially different) chemical moiety bearing a positive charge at physiological pH, a and b are, independently, a number between 3 and 6; and L is a linker]. The compounds may have different X groups (on both sides of the linker L) if each compound has a positive charge at a physiological pH, for example X1-X2-X3-L-X4-X5-X6, X1-X1-X1-L-X2-X3-X4, or X1-X1-X1-L-X2-X2-X2, or X1-X1-X1-L-X2-X2-X2 in the case of each having a positive charge. <P>COPYRIGHT: (C)2013,JPO&INPIT |
