| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a viral gene therapy agent to be delivered to a selected organ of a mammalian subject. <P>SOLUTION: This method for delivering the viral gene therapy agent includes: placing one or more catheters, wherein at least one or more of them has inflatably expandable members, within the venous vasculature which drains the organ; isolating the organ or section of the organ by occluding flow of blood within the venous vasculature which drains the organs or section of the organ by inflating one or more of the inflatably expandable members; delivering the viral gene therapy agent with a dosage which causes a rise in blood pressure of no more than 40% above the normal venous pressure in the isolated organ or isolated section of the organ; and allowing the gene therapy agent to persist within the isolated organ or section of the organ for a period of time sufficient for transduction of a therapeutically effective amount of the agent. <P>COPYRIGHT: (C)2013,JPO&INPIT |
