发明名称 |
AROMATIC COMPOUND, MODIFICATION CARRIER THAT USES SAME AND IS USED FOR SYNTHESIZING AN OLIGONUCLEOTIDE DERIVATIVE, OLIGONUCLEOTIDE DERIVATIVE, AND OLIGONUCLEOTIDE CONSTRUCT |
摘要 |
<p>The present invention provides an oligonucleotide derivative that enables to easily synthesize an oligonucleotide derivative chemically modified at the 3'-end with two moieties each having a benzene or pyridine structure with a few steps, an aromatic compound serving as a precursor for preparing the modification carrier for synthesizing oligonucleotide derivative, and the oligonucleotide derivative and the oligonucleotide construct using the same, that is chemically modified at the 3'-end with two moieties each having a benzene or pyridine structure, and has good permeability through a cell membrane and excellent nuclease resistance. The modification carrier for synthesizing oligonucleotide derivative, comprising a unit and a carrier carrying the unit directly or via a linker, wherein the unit is represented by the formula (a): wherein, R 1 to R 6 each independently represent hydrogen or a substituent other than hydrogen; Z 1 and Z 2 each independently represent CH or nitrogen; and X represents oxygen or sulfur.</p> |
申请公布号 |
EP2511260(A1) |
申请公布日期 |
2012.10.17 |
申请号 |
EP20100835998 |
申请日期 |
2010.12.08 |
申请人 |
GIFU UNIVERSITY |
发明人 |
KITADE, YUKIO;KITAMURA, YOSHIAKI |
分类号 |
C07C275/24;A61K31/7088;A61K31/7105;A61K31/711;A61K31/713;A61K48/00;C07C335/12;C07D213/40;C07F7/10;C07F9/09;C07F9/6558;C07H21/00;C07H21/02;C07H21/04;C12N15/09;C12Q1/68 |
主分类号 |
C07C275/24 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|