ANTI-ALLERGY COMPOSITION COMPRISING (1R,2R,3R)-3-AMINOCYCLOPENTANE-1,2-DIOL

摘要

PURPOSE: A composition for anti-allergy including (1R,2R,3R)-3-amino cyclopentane -1,2- diol is provided to suppress expression of COX-2, TNF- A, IL-10 and IL-4 genes by(1R,2R,3R)-3-amino cyclopentane -1,2- diol and to suppress the activation of AKT-, ERK-, JNK-, and p38- signal transmission paths. CONSTITUTION: A composition for anti-allergy includes a compound represented by chemical formula 1 as an active ingredient. The composition has the following functions: suppressing the expression of COX-2, TNF- A, IL-10 and IL-4 genes; suppressing the activation of AKT-, ERK-, JNK-, p38- signal transmission paths; suppressing the activation of NF-kB; and suppressing the activation of lipoxygenase. The composition for anti-allergy includes a compound represented by chemical formula 1 as the active ingredient. The pharmaceutical composition is manufactured into a tablet, pellet, powder, granule, capsule, suspension agent, liquid medicine, emulsion, syrup, sterilized aqueous solution, non-aqueous solvent, suspension agent, PedHIB or suppository form. A food composition for anti-allergy includes the compound represented by the chemical formula 1 as the active ingredient.