发明名称 |
(Poly) aminoalkylaminoalkylamide, alkyl-urea, or alkyl-sulfonamide derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents |
摘要 |
The present invention relates to new derivatives of epipodophyllotoxin 4-substituted with an optionally substituted (poly)aminoalkylaminoalkylamidc, or alkyl-urea or alkyl-sulfonamide chain, a process for preparing them and their use as a medicine as an anticancer agent. Formula (1) wherein: —R represents hydrogen or C1-4alkyl, —A represents CO(CH2)n or CONH(CH2)n where n=2, 3, 4, or 5, —R1 and R2 are as described herein. |
申请公布号 |
US8288567(B2) |
申请公布日期 |
2012.10.16 |
申请号 |
US20090737645 |
申请日期 |
2009.08.19 |
申请人 |
IMBERT THIERRY;GUMINSKI YVES;BARRET JEAN-MARC;KRUCZYNSKI ANNA;PIERRE FABRE MEDICAMENT |
发明人 |
IMBERT THIERRY;GUMINSKI YVES;BARRET JEAN-MARC;KRUCZYNSKI ANNA |
分类号 |
C07D307/77 |
主分类号 |
C07D307/77 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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