发明名称 Thiophenediamine derivative having urea structure
摘要 A compound of formula (1): wherein R1 and R2 represent hydrogen, lower alkyl, lower alkenyl, lower alkynyl or R3 represents hydroxyl, lower alkoxy, lower cycloalkyloxy, aryloxy, carboxy, lower alkoxycarbonyl, or NRaRb of the formula R4 and R5 represent halogen, lower alkyl, hydroxyl, or lower alkoxy; R6 represents halogen, lower alkyl, aryl, heterocyclic, hydroxy, lower alkoxy, mercapto, lower alkylthio, lower alkylcarbonyl, amino, nitro or cyano; R7 represents lower alkyl, hydroxyl or lower alkoxy; Ra and Rb represent hydrogen or lower alkyl; ring A represents a cyclic hydrocarbon or a heterocyclic ring; ring B represents a heterocyclic ring; X represents lower alkylene; Z represents a single bond or lower alkylene; Y represents lower alkylene and W1—W2 represents CH—CH, or Y represents a single bond and W1—W2 represents N—CH, CH—N or CH—CH; and 1, m, n and o represent 0, 1, 2, or 3.
申请公布号 US8288380(B2) 申请公布日期 2012.10.16
申请号 US201213448674 申请日期 2012.04.17
申请人 MOGI HIROYUKI;TAJIMA HISASHI;MISHINA NORIKO;YAMAZAKI YUSUKE;YONEDA SHINJI;WATANABE KATSUHIKO;FUJIKAWA JUNKO;YAMAMOTO MINORU;SANTEN PHARMACEUTICAL CO., LTD. 发明人 MOGI HIROYUKI;TAJIMA HISASHI;MISHINA NORIKO;YAMAZAKI YUSUKE;YONEDA SHINJI;WATANABE KATSUHIKO;FUJIKAWA JUNKO;YAMAMOTO MINORU
分类号 A61K31/5377;A61K31/381;A61K31/4436;A61K31/4439;A61K31/444;A61K31/496;A61P27/02;A61P27/06;C07D333/36;C07D409/12;C07D409/14;C07D413/12;C07D417/14 主分类号 A61K31/5377
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