发明名称 |
TRIPTOLIDE DERIVATIVES FOR MODULATION OF APOPTOSIS AND IMMUNOSUPPRESSION |
摘要 |
Variously substituted carbonate and carbamate derivatives of triptolide compounds have good aqueous solubility and convert to biologically active compounds in vivo, at a rate which can be modulated by varying the substitution on the prodrug. The prodrugs are useful as immunosuppressive, anti-inflammatory and anticancer agents.
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申请公布号 |
CA2485794(C) |
申请公布日期 |
2012.10.16 |
申请号 |
CA20032485794 |
申请日期 |
2003.05.29 |
申请人 |
PHARMAGENESIS, INC. |
发明人 |
DAI, DONGCHENG;MUSSER, JOHN H.;LENNOX, EDWIN S. |
分类号 |
C07J73/00;A61K31/365;A61K31/58;A61P35/00;A61P37/06;C07D493/04;C07D493/22;C07J71/00 |
主分类号 |
C07J73/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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