发明名称 |
GAS57 mutant antigens and GAS57 antibodies |
摘要 |
The invention provides mutants of GAS57 which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections.
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申请公布号 |
US8287885(B2) |
申请公布日期 |
2012.10.16 |
申请号 |
US20080676192 |
申请日期 |
2008.09.12 |
申请人 |
MARGARIT Y ROS IMMACULADA;GRANDI GUIDO;ZINGARETTI CHIARA;NOVARTIS AG |
发明人 |
MARGARIT Y ROS IMMACULADA;GRANDI GUIDO;ZINGARETTI CHIARA |
分类号 |
A61K39/09;A61K38/00;A61K39/00;A61K39/02;C07K1/00 |
主分类号 |
A61K39/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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