发明名称 |
MULTIFUNCTIONAL RADICAL QUENCHERS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION |
摘要 |
<p>The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.</p> |
申请公布号 |
CA2830581(A1) |
申请公布日期 |
2012.10.11 |
申请号 |
CA20122830581 |
申请日期 |
2012.04.04 |
申请人 |
ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THESTATE OF ARIZONA, ACTI NG FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY |
发明人 |
HECHT, SIDNEY;KHDOUR, OMAR;CHOWDHURY, SANDIPAN ROY;TALUKDER, POULAMI |
分类号 |
C07D213/74;A61K31/64;A61P39/06 |
主分类号 |
C07D213/74 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|