发明名称 |
D-APTIDE AND RETRO-INVERSO APTIDE WITH MAINTAINED TARGET AFFINITY AND IMPROVED STABILITY |
摘要 |
The present invention is characterized by a D-aptamer-like peptide (D-Aptide) or retro-inverso Aptide which specifically binds to a target comprising: (a) a structure stabilizing region comprising parallel, antiparallel or parallel and antiparallel D-amino acid strands with interstrand noncovalent bonds; and (b) a target binding region I and a target binding region II comprising randomly selected n and m D-amino acids, respectively, and coupled to both ends of the structure stabilizing region. The D-Aptide or retro-inverso Aptide has the sequence of the same or opposite direction to L-Aptide, wherein the stability to proteases is improved while maintaining the affinity to a target compared with L-Aptide. The D-Aptide of the present invention has substantially the same target affinity and a remarkably improved stability compared with L-Aptide which is different from a general technical knowledge. |
申请公布号 |
WO2012138176(A2) |
申请公布日期 |
2012.10.11 |
申请号 |
WO2012KR02631 |
申请日期 |
2012.04.06 |
申请人 |
GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY;JON, SANG-YONG;KIM, SUNG-HYUN |
发明人 |
JON, SANG-YONG;KIM, SUNG-HYUN |
分类号 |
G01N33/68;C07K2/00;C40B40/10;G01N33/53 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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