Preparing E-configured alkene compounds comprises reacting Z-configured alkene compounds under isomerization conditions, where the E-configured alkene compound is present in the solid phase

摘要

Preparing E-configured alkene compounds (I) comprises reacting Z-configured alkene compounds (I) under isomerization conditions, where the E-configured alkene compound is present in the solid phase. Preparing E-configured alkene compounds of formula (R 1>-[A 1>-Z 1>] m-A 2>-(CH 2) n-CH=CH-R 2>)(I) comprises reacting Z-configured alkene compounds (I) under isomerization conditions, where the E-configured alkene compound is present in the solid phase. Either R 1> : 1-15C optionally halogenated alkyl, in which at least one CH 2group can be replaced by -CC-, -CH=CH-, -CF=CF-, -(CO)O-, -O(CO)-, -(CO)- or -O- in such a manner that O atoms are not directly linked with one another, H, F, Cl, Br, CN, OH, CF 3, OCF 3, SCN, NCS or SF 5; and A 1> : trans-1,4-cyclohexylene or cyclohexenylene (where one or two non-adjacent CH 2groups are optionally replaced by -O- and/or -S-, and H is optionally replaced by F), or 1,4-phenylene (where one or two CH groups are optionally replaced by N and at least one H atom is substituted by Br, Cl, F, CN, 3-6C cycloalkyl, 1-10C alkyl (optionally mono- or poly-fluorinated), 1-10C alkoxy (optionally mono- or poly-fluorinated) or 1,4-bicyclo(2,2,2)-octylene, cylcobut-1,3-diyl, spiro[3.3]heptane-2,6-diyl, thiophene-2,5-diyl, naphthalene-2,6-diyl or anthracene-2,6-diyl (where at least one CH group is optionally replaced by N, and at least one H atom is optionally replaced by Br, Cl, F, CN, 3-6C cycloalkyl, 1-10C alkyl (optionally mono- or poly-fluorinated), 1-10C alkoxy (optionally mono- or poly-fluorinated), and at least one double bond is optionally replaced by single bond; or R 1>A 1>= cyclohexanone-4-yl; R 2> : 1-15C optionally halogenated alkyl, in which at least one CH 2group is replaced by -CC-, -CH=CH-, -CF=CF-, -(CO)O-, -O(CO)-, -(CO)- or -O- in such a way that O atoms are not directly linked with one another; m : 1-3; n : 0-4, preferably 0; A 2> : A 1>; and Z1 : single bond, -CC-, -CH=CH-, -CH 2O-, -(CO)O-, -CF 2O-, -CF 2CF 2-, -CH 2CF 2-, -CH 2CH 2-, -(CH 2) 4-, -CH=CF- or -CF=CF-, where asymmetric bridges may be oriented to both sides.