发明名称 |
COMPOSITION FOR EXTERNAL APPLICATION |
摘要 |
<p>Provided is a composition for external application, which comprises pyrroloquinolinequinone (PQQ) or a pharmaceutically acceptable salt thereof and a surfactant and has a pH value of 4-6. When a surfactant is added to a composition containing PQQ or a salt thereof, the stability of PQQ or the salt thereof is deteriorated significantly. The storage stability of PQQ or a salt thereof in a composition comprising PQQ or the salt thereof and a surfactant can be improved by adjusting the pH value of the composition to 4-6.</p> |
申请公布号 |
WO2012137932(A1) |
申请公布日期 |
2012.10.11 |
申请号 |
WO2012JP59549 |
申请日期 |
2012.04.06 |
申请人 |
ROHTO PHARMACEUTICAL CO., LTD.;FUKUSHIMA, KAZUHIRO |
发明人 |
FUKUSHIMA, KAZUHIRO |
分类号 |
A61K8/49;A61K8/86;A61K31/437;A61K47/10;A61Q1/14;A61Q19/00;C07D471/04 |
主分类号 |
A61K8/49 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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