METHODS FOR DECREASING BODY WEIGHT AND TREATING DIABETES

摘要

Disclosed herein are methods of treating diabetes (e.g., increasing glucose tolerance, reducing insulin resistance, and decreasing serum lipids) and/or reducing body weight (e.g., treating overweight or obesity) including administering a therapeutically effective amount of a composition including an inhibitor of hypoxia- inducible factor la (HIF1a) to a subject with diabetes or a subject in need of reduction of body weight. The HIF1a inhibitor can be administered in combination with a pharmaceutically acceptable carrier. In some examples, the HIF1a inhibitor is administered orally.