发明名称 |
PROTEASE CLEAVAGE SITE PEPTIDES AS AN HIV VACCINE |
摘要 |
Instead of generating immune responses to several HIV proteins and risk over activating more CD4+ T cells (easy targets for HIV-1 infection) as current candidate vaccines try to do, a lower magnitude, narrowly focused, well maintained virus specific CD8+ T cell response to multiple subtypes should destroy and eliminate a few founder viruses without inducing inflammatory responses that may activate more CD4+ T cells and provide more targets for HIV-1 virus infection. Specifically, described herein is a method that focuses the immune response to the 12 protease cleavage sites. |
申请公布号 |
WO2012135959(A1) |
申请公布日期 |
2012.10.11 |
申请号 |
WO2012CA50220 |
申请日期 |
2012.04.05 |
申请人 |
HER MAJESTY THE QUEEN IN RIGHT OF CANADA AS REPRESENTED BY THE MINISTER OF HEALTH;LUO, MA |
发明人 |
LUO, MA |
分类号 |
C12N15/49;A61K9/14;A61K39/21;A61P31/18;A61P37/04;C07K7/08;C07K14/155;C07K14/16;C07K17/00 |
主分类号 |
C12N15/49 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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