发明名称 |
USE OF A SPIROLIDE, ANALOGUES AND DERIVATIVES FOR TREATING AND/OR PREVENTING PATHOLOGICAL CONDITIONS LINKED TO THE TAU AND BETA-AMYLOID PROTEINS |
摘要 |
The present invention is in the field of biomedicine. Specifically, it relates to the use of a spirolide compound with the chemical structure: for preparing a drug for the prevention and/or treatment of a pathology related to the increase in &bgr;-amyloid protein and/or hyperphosphorylation of tau protein compared to control, where said spirolide compound is administered in the amount necessary to reach a concentration in the serum of equal to or less than 50 nM. The amount administered is preferably the amount necessary to reach a concentration in the serum of between 0.5 nM and 50 nM.
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申请公布号 |
US2012258956(A1) |
申请公布日期 |
2012.10.11 |
申请号 |
US201013500018 |
申请日期 |
2010.09.29 |
申请人 |
BOTANA LOPEZ LUIS M.;ALONSO LOPEZ EVA;VALE GONZALEZ CARMEN |
发明人 |
BOTANA LOPEZ LUIS M.;ALONSO LOPEZ EVA;VALE GONZALEZ CARMEN |
分类号 |
A61K31/55;A61K31/365;A61P25/00;A61P25/16;A61P25/28 |
主分类号 |
A61K31/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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