BENZOMORPHOLINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF

摘要

Disclosed are benzomorpholine derivatives as represented by the following formula (I) and pharmaceutical compositions comprising the derivatives as well as methods of preparation thereof, R1, R2 and R3 are as defined in the specification. The benzomorpholine derivatives of formula (I) are an inhibitor of phosphatidylinositol 3-kinases (PI3K), and have a good inhibitory effect on PI3K and on cancer cell proliferation, thereby serving as a therapeutic agent for the treatment of tumors.