| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide RNAi-mediated inhibition of RHO Kinase for treatment of ocular disorders. <P>SOLUTION: RNA interference is provided for inhibition of Rho kinase mRNA expression for treating patients with ocular disorders, particularly for treating intraocular pressure, ocular hypertension and glaucoma. Rho kinase mRNA targets include mRNA for ROCK1 and ROCK2. The invention provides a method of attenuating expression of a Rho kinase mRNA in a subject. The method includes administering to the subject a composition comprising an effective amount of interfering RNA having a length of 19 to 49 nucleotides and a pharmaceutically acceptable carrier. <P>COPYRIGHT: (C)2013,JPO&INPIT |
