发明名称 |
CROSSLINKED HYALURONIC ACID IN EMULSION |
摘要 |
The present invention relates to methods of producing crosslinked hyaluronic acid microbeads, as well as the produced microbeads, said method comprising the steps of: (a) providing an aqueous alkaline solution comprising hyaluronic acid, or a salt thereof; (b) forming microdroplets having a desired size from the mixed solution of step (a) in an organic or oil phase to form a water in organic or water in oil (W/O) emulsion, wherein the amount of oil phase used is of from 20 to less than 50% by weight based on the sum of oil phase and water; (c) adding a solution comprising a crosslinking agent to the emulsion, whereby the reaction of hyaluronic acid with the crosslinking agent takes place to provide crosslinked hyaluronic acid microbeads; and (d) optionally working up the dispersion of crosslinked hyaluronic acid microbeads obtained in step (c). |
申请公布号 |
US2012258155(A1) |
申请公布日期 |
2012.10.11 |
申请号 |
US201213529425 |
申请日期 |
2012.06.21 |
申请人 |
WENK HANS HENNING;FARWICK MIKE;NATTLAND SANDRA;MACZKIEWITZ URSULA;MOELHOLM MALLE BIRGITTE;NOVOZYMES BIOPOLYMER A/S;EVONIK GOLDSCHMIDT GMBH |
发明人 |
WENK HANS HENNING;FARWICK MIKE;NATTLAND SANDRA;MACZKIEWITZ URSULA;MOELHOLM MALLE BIRGITTE |
分类号 |
A61K8/73;A61K8/11;A61Q1/02;A61Q5/00;A61Q15/00;A61Q17/04;A61Q19/00;A61Q19/04;A61Q19/08;C08B37/08 |
主分类号 |
A61K8/73 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|