MODIFIED LAMININ AND USE THEREOF

摘要

Provided is a modified laminin characterized in that a cell growth regulatory molecule is bound to at least one site of the N-terminus of an a-chain, the C-terminus of an a-chain, the N-terminus of a ß-chain, and the N-terminus of a ?-chain of a laminin or a laminin fragment forming a hetero-trimer. Also provided are a culturing method for culturing cells in the presence of the modified laminin, a method for establishing iPS cells in the presence of the modified laminin, and a culture base material coated with the modified laminin. By culturing human stem cells in a xeno-free environment using the modified laminin of the invention, human stem cells which are highly safe and can be applied to regenerative medicine can be provided.