发明名称 |
DIAGNOSIS AND TREATMENT OF AUTOMMUNE DISEASES BY TARGETING AUTOMMUNE-RELATED B CELLS (ABCS) |
摘要 |
The present invention is directed to methods of diagnosis and treatment of autoimmune diseases based on the identification of a novel population of B cells known as Autoimmune- or Age-related B cells ("ABCs"). These cells express the CDI Ic cell surface protein and exhibit a unique gene expression profile. The ABCs increase in numbers in subjects that are prone to developing autoimmune diseases or in healthy individuals, particularly females, as they age. Accordingly, the present invention includes methods and kits for diagnosis of autoimmune diseases based on the detection of the ABCs before overt symptoms of the disease become detectable. The present invention also includes methods of treatment of autoimmune diseases by targeting the ABCs, as well as methods for assessing the efficacy of treatments of autoimmune diseases. |
申请公布号 |
EP2359139(A4) |
申请公布日期 |
2012.10.10 |
申请号 |
EP20090825537 |
申请日期 |
2009.11.09 |
申请人 |
NATIONAL JEWISH HEALTH |
发明人 |
RUBTSOV, ANATOLY;KAPPLER, JOHN;MARRACK, PHILIPPA |
分类号 |
G01N33/564;G01N33/50;G01N33/68 |
主分类号 |
G01N33/564 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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