| 摘要 |
PURPOSE: A composition containing amino coumarin-based compounds is provided to suppress osteoclast differentiation and to suppress bone resorption. CONSTITUTION: A composition for preventing or treating bone metabolic diseases contains clorobiocin, novobiocin, or coumemycin A1 as an active ingredient. The bone metabolic diseases are osteoporosis, ricket, malacosteon, chronic osteoporosis, bone metastatic lesion, periodontal disease, inflammatory bone resorption disease, or inflammatory bone resorption disease. A health functional food for preventing or treating bone metabolic diseases contains clorobiocin, novobiocin, or coumemycin A1 as an active ingredient. [Reference numerals] (AA,BB) RANKL+coumemycin A1 |
