| 发明名称 |
Method of treating neurodegenerative disease |
| 摘要 |
Aspects featured in the invention relate to compositions and methods for inhibiting alpha-synuclein (SNCA) gene expression, such as for the treatment of neurodegenerative disorders. An anti-SNCA agent featured herein that targets the SNCA gene can have been modified to alter distribution in favor of neural cells. |
| 申请公布号 |
EP2508608(A1) |
申请公布日期 |
2012.10.10 |
| 申请号 |
EP20120165414 |
申请日期 |
2004.06.09 |
| 申请人 |
ALNYLAM PHARMACEUTICALS INC.;MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH |
发明人 |
BUMCROT, DAVID;FARRER, MATTHEW J.;MARAGANORE, DEMETRIUS;VORNLOCHER, HANS-PETER |
| 分类号 |
C12N15/113;A61K;A61K31/713;A61K48/00;C07H21/02;C12Q1/68 |
主分类号 |
C12N15/113 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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