发明名称 |
METHOD OF PRODUCING TECHNETIUM-99m LABELLED NANOCOLLOID |
摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a method of producing radioactive technetium-99m labelled nanocolloid. The method is characterised by adding a technetium-99m eluate to an aqueous suspension prepared from nanosized gamma-aluminium oxide powder with particle size of 7-10 nm and concentration of 0.5-0.7 mg/ml after bringing the pH of the medium to 4-5, followed by successive addition of ascorbic acid, tin (II) chloride dihydrate and gelatine in defined amounts. The obtained mixture is heated in a water bath at temperature 70-80C for 30 minutes, cooled to room temperature in an ultrasonic bath and then subjected to sterilisation filtration. ^ EFFECT: invention enables to obtain 99mTc-Al2O3 nanocolloid, used based on its size to conduct diagnostic research for which not less than 80% of the particles have size in the range of 20-100 nm, and the radiochemical purity of the preparation is higher than 90%. ^ 1 dwg, 2 tbl, 3 ex |
申请公布号 |
RU2463075(C1) |
申请公布日期 |
2012.10.10 |
申请号 |
RU20110127269 |
申请日期 |
2011.07.01 |
申请人 |
ROSSIJSKAJA FEDERATSIJA, OT IMENI KOTOROJ VYSTUPAET MINISTERSTVO OBRAZOVANIJA I NAUKI ROSSIJSKOJ FEDERATSII;GOSUDARSTVENNOE OBRAZOVATEL'NOE UCHREZHDENIE VYSSHEGO PROFESSIONAL'NOGO OBRAZOVANIJA "NATSIONAL'NYJISSLEDOVATEL'SKIJ TOMSKIJ POLITEKHNICHESKIJ UNIVERSITET" (GOU VPO NI TPU) |
发明人 |
SKURIDIN VIKTOR SERGEEVICH;STASJUK ELENA SERGEEVNA;VARLAMOVA NATAL'JA VALER'EVNA;SADKIN VLADIMIR LEONIDOVICH;NESTEROV EVGENIJ ALEKSANDROVICH;ROGOV ALEKSANDR SERGEEVICH |
分类号 |
A61K51/02;A61K51/12;A61K103/10;B82B3/00;B82Y5/00 |
主分类号 |
A61K51/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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