| 发明名称 |
METHOD OF OBTAINING BETULINIC ACID |
| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to pharmaceutical industry, in particular to method of obtaining betulinic acid. Method of obtaining betulinic acid, including betulin dispersing in donor coordinating solution, oxidation of betulin by chrome (IV) compound in presence of aluminium sulfate under specified conditions, purification of obtained betulonic acid and its reduction by sodium borohydride in isopropyl alcohol to betulinic acid. ^ EFFECT: method makes it possible to increase target product output. ^ 5 cl, 1 tbl, 4 ex |
| 申请公布号 |
RU2463041(C1) |
申请公布日期 |
2012.10.10 |
| 申请号 |
RU20110118847 |
申请日期 |
2011.05.10 |
| 申请人 |
GOSUDARSTVENNOE OBRAZOVATEL'NOE UCHREZHDENIE VYSSHEGO PROFESSIONAL'NOGO OBRAZOVANIJA "NIZHEGORODSKAJA GOSUDARSTVENNAJA MEDITSINSKAJA AKADEMIJA" MINISTERSTVA ZDRAVOOKHRANENIJA I SOTSIAL'NOGO RAZVITIJAROSSIJSKOJ FEDERATSII (GOU VPO NIZHGMA MINZDRAVSOT |
发明人 |
MEL'NIKOVA NINA BORISOVNA;USHKOVA TAT'JANA MIKHAJLOVNA;KISLITSIN ALEKSEJ NIKOLAEVICH;KLABUKOVA IRINA NIKOLAEVNA |
| 分类号 |
A61K31/015;C07J53/00;C07J63/00 |
主分类号 |
A61K31/015 |
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