发明名称 |
Genetic inhibition of double-stranded RNA |
摘要 |
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
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申请公布号 |
US8283329(B2) |
申请公布日期 |
2012.10.09 |
申请号 |
US20070905368 |
申请日期 |
2007.09.28 |
申请人 |
FIRE ANDREW Z.;KOSTAS STEPHEN A.;MONTGOMERY MARY K.;TIMMONS LISA;XU SIQUN;TABARA HIROAKI;DRIVER SAMUEL E.;MELLO CRAIG C.;THE CARNEGIE INSTITUTION OF WASHINGTON;THE UNIVERSITY OF MASSACHUSETTS |
发明人 |
FIRE ANDREW Z.;KOSTAS STEPHEN A.;MONTGOMERY MARY K.;TIMMONS LISA;XU SIQUN;TABARA HIROAKI;DRIVER SAMUEL E.;MELLO CRAIG C. |
分类号 |
A01H5/00;A61K31/70;A01K67/027;A61K38/00;C07H21/04;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/113;C12Q1/68 |
主分类号 |
A01H5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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