发明名称 |
Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
摘要 |
Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that are VEGF or VEGF-C inhibitors; polynucleotides encoding the polypeptides; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the polypeptides. Methods of inhibiting endothelial cell proliferation are also provided.
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申请公布号 |
US8282931(B2) |
申请公布日期 |
2012.10.09 |
申请号 |
US20100879740 |
申请日期 |
2010.09.10 |
申请人 |
ALITALO KARI;JOUKOV VLADIMIR;VEGENICS PTY LIMITED |
发明人 |
ALITALO KARI;JOUKOV VLADIMIR |
分类号 |
A61K39/00;A61K38/00;C07K14/00;C07K14/52;C07K14/71 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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