The invention is directed an anti-CCR5 antibody which comprises (i) two light chains, each light chain comprising the expression product of a plasmid designated pVK:HuPRO140-VK (ATCC Deposit Designation PTA-4097), and (ii) two heavy chains, each heavy chain comprising an expression product of either a plasmid designated pVg1:HuPRO140 HG2-VH (ATCC Deposit Designation PTA-4098) or a plasmid designated pVgl:HuPR0140 (mutB+D+I)-VH (ATCC Deposit Designation PTA-4099) or a fragment thereof which binds to CCR5 on the surface of a human cell.
申请公布号
CA2476901(C)
申请公布日期
2012.10.09
申请号
CA20032476901
申请日期
2003.02.21
申请人
PROGENICS PHARMACEUTICALS, INC.;PROTEIN DESIGN LABS, INC.
发明人
OLSON, WILLIAM C.;MADDON, PAUL J.;TSURUSHITA, NAOYA;HINTON, PAUL R.;VASQUEZ, MAXIMILLANO