发明名称 |
CRYSTALLINE FORMS OF THE TRI-MESYLATE SALT OF PERPHENAZINE-GABA AND PROCESS OF PRODUCING THE SAME. |
摘要 |
<p>Novel crystalline form of perphenazine 4-aminobutyrate trimesylate and a process of producing the same are disclosed. The novel crystalline form is characterized by a unique XRPD pattern and a DSC that exhibits an endothermic peak at a relatively high temperature (e.g., higher than 209 °C). Also disclosed are a process of preparing perphenazine 4- aminobutyrate trimesylate by in situ deprotection and salification, in a single-step synthesis, and a highly pure perphenazine 4-aminobutyrate trimesylate obtained thereby. Uses of any of the described perphenazine 4-aminobutyrate trimesylate are also disclosed.</p> |
申请公布号 |
MX2012009821(A) |
申请公布日期 |
2012.10.09 |
申请号 |
MX20120009821 |
申请日期 |
2011.02.24 |
申请人 |
RAMOT AT TEL-AVIV UNIVERSITY LTD. |
发明人 |
ADA REPHAELI;IRIT GIL-AD;ABRAHAM WEIZMAN;ABRAHAM NUDELMAN;MAZAL SHAUL;EFRAT HALBFINGER |
分类号 |
A61K31/54 |
主分类号 |
A61K31/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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