发明名称 |
Coiled-coil-helikale lipopeptidbundter samt syntetiske viruslignende partikler |
摘要 |
<p>The invention relates to lipopeptide building blocks consisting of a peptide chain comprising a coiled-coil domain, linked covalently to a lipid moiety comprising long alkyl or alkenyl chains, and optionally linked to an antigen; and to helical lipopeptide bundles and synthetic virus-like particles formed by aggregation. The nanometer size and shape of these bundles and particles, their stability under aqueous physiological conditions, their chemical composition, the possibility to incorporate B- and T-cell epitopes, and their production by chemical synthesis, make them highly suitable as vaccine delivery vehicles.</p> |
申请公布号 |
DK2121732(T3) |
申请公布日期 |
2012.10.08 |
申请号 |
DK20070856406T |
申请日期 |
2007.12.06 |
申请人 |
UNIVERSITAET ZUERICH PROREKTORAT FORSCHUNG |
发明人 |
BOATO, FRANCESCA;FREUND, ANNABELLE;GHASPARIAN, ARIN;MOEHLE, KERSTIN;ROBINSON, JOHN A.;THOMAS, RICHARD M. |
分类号 |
C07K14/005;A61K39/00 |
主分类号 |
C07K14/005 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|