BIOMIMETIC CHEMICAL SENSORS USING NANOELECTRONIC READOUT OF OLFACTORY RECEPTORS

摘要

Biomimetic sensor devices that utilize proteins - such as G-protein coupled receptors - and are useful in high-sensitivity analysis of analyte-containing samples. These sensors may be used to determine the presence or concentration of one or more analytes in a sample. Methods of fabricating the devices include Three-terminal transistor circuits were fabricated from carbon nanotubes grown on oxidized silicon substrates by catalytic chemical vapor deposition, with the heavily doped substrate used as a back gate electrode. Methods of using the devices to assay samples include contacting a sample with a device comprising a transmembrane protein disposed in a lipid, an amphiphile, or both, the device comprising a semiconductor material in electronic communication with the transmembrane protein; and measuring a first electronic characteristic of the device when the device is contacted with the sample.