发明名称 |
METHODS AND COMPOSITIONS FOR CYTOMEGALOVIRUS IL-10 PROTEIN |
摘要 |
The present invention provides methods and compositions for treating and/or preventing a cytomegalovirus infection in a subject, comprising administering to the subject an effective amount of a cytomegalovirus IL-10 protein modified to have reduced functional activity while retaining immunogenicity. The present invention further provides nucleic acid molecules encoding a cytomegalovirus IL-10 protein or fragment thereof of this invention as well as vectors comprising such nucleic acids. Also provided herein are neutralizing antibodies that specifically bind cmvIL-10. |
申请公布号 |
WO2012135177(A2) |
申请公布日期 |
2012.10.04 |
申请号 |
WO2012US30666 |
申请日期 |
2012.03.27 |
申请人 |
UAB RESEARCH FOUNDATION;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;WALTER, MARK R.;BARRY, PETER A. |
发明人 |
WALTER, MARK R.;BARRY, PETER A. |
分类号 |
C07K19/00;A61K38/20;A61K39/12;A61P31/20;C07K14/045;C07K14/54;C12N15/13 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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