发明名称 |
Methods for Diagnosing and Treating Cancer |
摘要 |
The invention provides methods for decreasing one or more symptoms of cancer in a patient requiring the steps of determining the activation or inactivation of the MK2 signaling pathway and, based on these determinations, administering either a MK2 inhibitor or a combination of a MK2 inhibitor and a chemotherapeutic agent, or a chemotherapeutic agent to the patient. The invention further provides methods for identifying a cancer patient that may selectively benefit from the administration of a chemotherapeutic agent, or the administration of a MK2 inhibitor or the combination of a MK2 inhibitor and a chemotherapeutic agent, requiring the steps of determining the activation or inactivation of the MK2 signaling pathway. The invention additionally provides methods and kits for diagnosing a chemotherapy-sensitive or chemotherapy-resistant cancer in a subject that require the step of (or reagents for) determining the activation or inactivation of the MK2 signaling pathway. The invention also provides methods of treating a cancer patient diagnosed as having a chemotherapy-sensitive or a chemotherapy-resistant cancer. |
申请公布号 |
US2012252737(A1) |
申请公布日期 |
2012.10.04 |
申请号 |
US201013499785 |
申请日期 |
2010.10.04 |
申请人 |
YAFFEE MICHAEL B.;REINHARDT HANS CHRISTIAN;MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
YAFFEE MICHAEL B.;REINHARDT HANS CHRISTIAN |
分类号 |
A61K38/02;A61K31/713;A61P35/00;C12Q1/68;C40B30/04;C40B40/06;C40B40/10;G01N21/64;G01N33/574 |
主分类号 |
A61K38/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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