The invention provides methods of reducing fouling of ultrafiltration membranes in processes wherein virus particles are removed from aqueous solutions comprising virus particles and at least one protein by adding a surfactant or non-surfactant, non-ionic agent to the aqueous solution prior to filtration. The invention also provides methods to dissociate protein aggregates or to reduce the formation of protein aggregates by adding a surfactant or non- surfactant, non- ionic agent to the protein solution.
申请公布号
WO2012134987(A1)
申请公布日期
2012.10.04
申请号
WO2012US30265
申请日期
2012.03.23
申请人
GENENTECH, INC.;BROWN, ARICK;JI, JUNYAN;LIU, JUN;WANG, YUCHANG, JOHN
发明人
BROWN, ARICK;JI, JUNYAN;LIU, JUN;WANG, YUCHANG, JOHN