发明名称 |
COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE |
摘要 |
The present invention relates to novel fluorophores and their use in combination with novel nucleic acid molecules, called aptamers, that bind specifically to the fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described. |
申请公布号 |
US2012252699(A1) |
申请公布日期 |
2012.10.04 |
申请号 |
US201013202250 |
申请日期 |
2010.02.18 |
申请人 |
JAFFREY SAMIE R.;PAIGE JEREMY S.;CORNELL UNIVERSITY |
发明人 |
JAFFREY SAMIE R.;PAIGE JEREMY S. |
分类号 |
G01N21/64;C07D233/70;C07D403/06;C07H21/02;C07H21/04;C12N1/16;C12N1/19;C12N1/20;C12N1/21;C12N5/04;C12N5/071;C12N5/10;C12N15/63;C40B40/06 |
主分类号 |
G01N21/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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