发明名称 |
GAIN-OF-FUNCTION BCL-2 INHIBITORS |
摘要 |
Compounds are described that are useful for treating an apoptosis-associated disease, which are specifically cytotoxic to tumor cells that are overexpressing Bcl-xL, and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-xL. Also described is a method for treating an apoptosis-associated disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an active compound that is specifically cytotoxic to tumor cells that are overexpressing Bcl-xL, and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-xL. Several scaffolds of active compounds are described.
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申请公布号 |
US2012252839(A1) |
申请公布日期 |
2012.10.04 |
申请号 |
US201213437795 |
申请日期 |
2012.04.02 |
申请人 |
HOCKENBERY DAVID;SIMON JULIAN;FRED HUTCHINSON CANCER RESEARCH CENTER |
发明人 |
HOCKENBERY DAVID;SIMON JULIAN |
分类号 |
A61K31/472;A61K31/05;A61K31/10;A61K31/12;A61K31/135;A61K31/15;A61K31/165;A61K31/166;A61K31/4245;A61K31/4402;A61K31/47;C07C233/65;C07C251/80;C07D211/04;C07D215/38;C07D217/22 |
主分类号 |
A61K31/472 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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