| 发明名称 |
PROCESS FOR THE PREPARATION OF DARUNAVIR |
| 摘要 |
A process for the preparation of Darunavir comprises the reacting of 4-amino-N-(2R,3S) (3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-benzenesulfonamide with (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol derivative in N-methyl-2-pyrrolidinone and isolating the resulting Darunavir. The process yields Darunavir with a very low level of the difuranyl impurity.
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| 申请公布号 |
US2012251826(A1) |
申请公布日期 |
2012.10.04 |
| 申请号 |
US201013496642 |
申请日期 |
2010.09.16 |
| 申请人 |
VELLANKI SIVA RAMA PRASAD;SAHU ARABINDA;KATUKURI ARAVIND KUMAR;VANAMA VIKRAM;KOTHARI SATISHBABU;PONNEKANTI VENKATA SURYANARAYANA;DATTA DEBASHISH |
发明人 |
VELLANKI SIVA RAMA PRASAD;SAHU ARABINDA;KATUKURI ARAVIND KUMAR;VANAMA VIKRAM;KOTHARI SATISHBABU;PONNEKANTI VENKATA SURYANARAYANA;DATTA DEBASHISH |
| 分类号 |
C07D493/04 |
主分类号 |
C07D493/04 |
| 代理机构 |
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