发明名称 N-NITROSOANILINE DERIVATIVE, HIGHLY REACTIVE ROS GENERATING AGENT USING THE SAME, AND METHOD FOR GENERATING HIGHLY REACTIVE ROS
摘要 <P>PROBLEM TO BE SOLVED: To provide an N-nitrosoaniline derivative capable of positionally and temporally controlling generation of peroxynitrite (ONOO<SP POS="POST">-</SP>) by ultraviolet irradiation, a highly reactive ROS generating agent using the N-nitrosoaniline derivative, and a method for generating the highly reactive ROS. <P>SOLUTION: The N-nitrosoaniline derivative is represented by structural formula (a). In the formula: R<SP POS="POST">1</SP>, R<SP POS="POST">2</SP>, R<SP POS="POST">3</SP>and R<SP POS="POST">4</SP>may be the same or different mutually and are each a hydrogen or an alkyl group; and R<SP POS="POST">5</SP>is one of an alkyl group, a carboxylic acid group, a carboxylic acid ester group, and a carboxylic acid amide group; provided that the case wherein R<SP POS="POST">1</SP>=R<SP POS="POST">2</SP>=R<SP POS="POST">5</SP>=methyl group and R<SP POS="POST">3</SP>=R<SP POS="POST">4</SP>=hydrogen and the case wherein R<SP POS="POST">5</SP>=methyl group and R<SP POS="POST">1</SP>=R<SP POS="POST">2</SP>=R<SP POS="POST">3</SP>=R<SP POS="POST">4</SP>=hydrogen are excluded. <P>COPYRIGHT: (C)2013,JPO&INPIT
申请公布号 JP2012188412(A) 申请公布日期 2012.10.04
申请号 JP20110131937 申请日期 2011.06.14
申请人 NAGOYA CITY UNIV 发明人 NAKAGAWA HIDEHIKO;IEDA NAOYA;SUZUKI TAKAYOSHI;MIYATA NAOKI
分类号 C07C243/06;A61K31/04;A61K41/00;A61P35/00 主分类号 C07C243/06
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