发明名称 |
NOVEL CATIONIC LIPIDS WITH SHORT LIPID CHAINS FOR OLIGONUCLEOTIDE DELIVERY |
摘要 |
The instant invention provides for novel cationic lipids with short lipid chains that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo while decreasing inflammatory toxicities.
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申请公布号 |
US2012253032(A1) |
申请公布日期 |
2012.10.04 |
申请号 |
US201013500733 |
申请日期 |
2010.09.20 |
申请人 |
CAMERON MARK;DAVIS JENNIFER R.;WANG WEIMIN;MERCK SHARP & DOHME CORPORATION |
发明人 |
CAMERON MARK;DAVIS JENNIFER R.;WANG WEIMIN |
分类号 |
C07J9/00;C07J43/00 |
主分类号 |
C07J9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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