发明名称 |
Peptide Conjugates Comprising Polyhistidine Sequence and Free Cysteine and Their Uses in Imaging |
摘要 |
Bioconjugates for use in imaging are disclosed include a linker sequence fused to a polypeptide capable of binding a target in a biological system. The linker sequence is designed so that it is capable of being radiolabelled, e.g. with a complex comprising a radionuclide, via a free cysteine residue and the polyhistidine sequence in the label that are both capable of simultaneously binding to a complex comprising the radionuclide. These interactions can improve significantly the rate and efficiency of radiolabelling compared to either protein with the His-tag or the free cysteine alone. Optionally, the free cysteine residue provides a site which can be covalently bonded to a moiety such as a second label, in a site-specific manner. |
申请公布号 |
US2012251446(A1) |
申请公布日期 |
2012.10.04 |
申请号 |
US201013390673 |
申请日期 |
2010.08.18 |
申请人 |
TAVARE RICHARD;MULLEN GREGORY;BLOWER PHILIP;TORRES MARTIN DE ROSALES RAFAEL;WILLIAMS JENNIFER;KING'S COLLEGE LONDON |
发明人 |
TAVARE RICHARD;MULLEN GREGORY;BLOWER PHILIP;TORRES MARTIN DE ROSALES RAFAEL;WILLIAMS JENNIFER |
分类号 |
A61K51/08;C07K19/00;C12P21/00;G01N21/17 |
主分类号 |
A61K51/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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