发明名称 |
METHOD FOR REMOVING TUMORIGENESIS-CAUSING CELLS AMONG STEM CELLS |
摘要 |
The present invention provides a lethal agent for undifferentiated cells and/or cells that would cause tumorigenesis, the lethal agent containing a virus vector in which a promoter for a nucleic acid for encoding an essential factor for replicating or assembling at least one virus has been replaced with a promoter for a gene which is specifically expressed in cancer cells or undifferentiated cells. The present invention further provides a lethal agent for undifferentiated cells and/or cells that would cause tumorigenesis, the lethal agent containing an expression vector including a nucleic acid for encoding a cytotoxic factor under the control of a promoter for a gene which is specifically expressed in cancer cells or undifferentiated cells. The present invention additionally provides a method for producing differentiated cells having a reduced risk of tumorigenesis, the method being characterized in that an aforesaid drug is brought into contact with a cell population induced to differentiate from stem cells, to thereby kill the undifferentiated cells or cells that would cause tumorigenesis remaining within the cell population. |
申请公布号 |
WO2012133674(A1) |
申请公布日期 |
2012.10.04 |
申请号 |
WO2012JP58414 |
申请日期 |
2012.03.29 |
申请人 |
KAGOSHIMA UNIVERSITY;KOSAI, KEN-ICHIRO;MITSUI, KAORU |
发明人 |
KOSAI, KEN-ICHIRO;MITSUI, KAORU |
分类号 |
A61K35/76;A61K35/12;A61K48/00;A61P35/00;A61P43/00;C12N5/10;C12N15/09;C12Q1/02;G01N33/15;G01N33/50 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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