METHODS AND COMPOSITIONS FOR MESENCHYMAL STEM CELL PROLIFERATION

摘要

Provided is a method for increasing proliferation of mesenchymal stem cells. The method entails contacting the cells with 6-bromoindirubin-3' -oxime (BIO). This results in robust proliferation and "sternness" in a dose-dependent fashion, as indicated by the gene expression of two stem cell genes: Sox2 and Nanog.