发明名称 |
NANOMETER-SCALE OPTICAL IMAGING BY THE MODULATION TRACKING (MT) METHOD |
摘要 |
An optical imaging method based on a feedback principle in which the specific scan pattern is adapted according to the shape of the sample. The feedback approach produces nanometer-resolved three dimensional images of very small and moving features in live cells and in a matter of seconds. Images of microvilli in live cultured opossum kidney cells expressing NaPi co-transporter proteins with different GFP constructs and images of cell protrusions in a collagen matrix are produced with a resolution of about 20 nm. Along cell protrusions in three dimensional cellular adhesions could be identified to the extracellular matrix.
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申请公布号 |
US2012250000(A1) |
申请公布日期 |
2012.10.04 |
申请号 |
US201213435387 |
申请日期 |
2012.03.30 |
申请人 |
LANZANO LUCA;DIGMAN MICHELLE;GRATTON ENRICO;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
LANZANO LUCA;DIGMAN MICHELLE;GRATTON ENRICO |
分类号 |
G01C3/08;G01B11/24 |
主分类号 |
G01C3/08 |
代理机构 |
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代理人 |
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地址 |
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