发明名称 |
Vanilloid Fatty Hydroxamates as Therapeutic Anti-inflammatory Pharmaceuticals |
摘要 |
Three unique subtypes of N-hydroxyamides and N-hydroxycarbamates containing both the vanilloid moiety (4-hydroxy-3-methoxybenzyl) and a lipophilic aliphatic moiety. Also disclosed are direct syntheses of these vanilloid fatty hydroxamates. The compounds possess inhibitory activity against the enzymes fatty acid amide hydrolase (FAAH) and matrix metallo-proteinase 9 (MMP-9). In addition, these substances bind to the calcium channel protein TRPV1 and inhibit vesicant-induced inflammation in skin and cornea. The compounds have utility in treating topical or systemic inflammatory processes in the skin and/or eye. |
申请公布号 |
US2012252891(A1) |
申请公布日期 |
2012.10.04 |
申请号 |
US201213422565 |
申请日期 |
2012.03.16 |
申请人 |
LASKIN JEFFREY D.;HEINDEL NED D.;LACEY CARL JEFFREY;PILLAI ABHILASH N.;GORDON MARION;HECK DIANE E.;UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY;LEHIGH UNIVERSITY;RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY |
发明人 |
LASKIN JEFFREY D.;HEINDEL NED D.;LACEY CARL JEFFREY;PILLAI ABHILASH N.;GORDON MARION;HECK DIANE E. |
分类号 |
A61K31/27;A61K31/16;A61K31/165;A61P17/00;A61P27/02;A61P29/00;C07C231/08;C07C233/01;C07C233/02;C07C261/00 |
主分类号 |
A61K31/27 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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