发明名称 |
METHODS FOR TREATMENT OF MELANOMA |
摘要 |
<p>The present inventionis directed to methods for treatment of melanoma using an inhibitor of dihydroorotate dehydrogenase (DHODH) and to combination therapies that involve administering to a subject an inhibitor of oncogenic BRAF (e.g. BRAF(V600E)), as well as an inhibitor of dihydroorotate dehydrogenase (DHODH). Assays for identifying compounds useful for the treatment of melanoma are also provided. The methods herein are directed to screening for compounds or agents that inhibit neural crest progenitor formation in a zebra fish model of melanoma.</p> |
申请公布号 |
WO2012109329(A3) |
申请公布日期 |
2012.10.04 |
申请号 |
WO2012US24295 |
申请日期 |
2012.02.08 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION;ZON, LEONARD;WHITE, RICHARD M.;DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
ZON, LEONARD;WHITE, RICHARD M. |
分类号 |
A61K31/02;A61K31/135;A61K31/42 |
主分类号 |
A61K31/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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