发明名称 |
Modified clostridial toxins with enhanced translocation capability and enhanced targeting activity |
摘要 |
The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain, a translocation facilitating domain and an enhanced targeting domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins. |
申请公布号 |
EP2505592(A1) |
申请公布日期 |
2012.10.03 |
申请号 |
EP20120168868 |
申请日期 |
2007.07.10 |
申请人 |
ALLERGAN, INC. |
发明人 |
STEWARD, LANCE E.;FRANCIS, JOSEPH;FERNANDEZ-SALAS, ESTER;GILMORE, MARCELLA A.;LI, SHENGWEN;AOKI, KEI ROGER |
分类号 |
C07K14/33;A61K38/16 |
主分类号 |
C07K14/33 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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