发明名称 |
ANTAGONISTS OF IL-6 TO RAISE ALBUMIN AND/OR LOWER CRP |
摘要 |
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to improve survivability or quality of life of a patient in need thereof. In preferred embodiments, the anti-IL-6 antibodies will be humanized and/or will be aglycosylated. Also, in preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level or a reduced serum albumin level prior to treatment. In another preferred embodiment, the patient's Glasgow Prognostic Score will be increased and survivability will preferably be improved. |
申请公布号 |
EP2504030(A2) |
申请公布日期 |
2012.10.03 |
申请号 |
EP20100833906 |
申请日期 |
2010.11.24 |
申请人 |
ALDER BIOPHARMACEUTICALS, INC. |
发明人 |
SMITH, JEFFREY T. L. |
分类号 |
A61K39/395;A61K38/08;A61K38/10;A61K38/16;A61P19/00;A61P19/10;A61P35/00;C07K16/24 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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