| 发明名称 |
INTRABODIES WITH DEFINED FRAMEWORK THAT IS STABLE IN A REDUCING ENVIRONMENT AND APPLICATIONS THEREOF |
| 摘要 |
A method for the isolation of CDRs in a defined framework that is stable and soluble in reducing environment is described as well as thus obtainable scFv. Starting from such scFv with defined framework a scFv library can be generated wherein the framework is conserved while at least one complementary determining region (CDR) is randomized. Such library, e.g. in yeast cells, is suitable for screening for antibody/CDR-interactions or for screening for antibodies. |
| 申请公布号 |
CA2396534(C) |
申请公布日期 |
2012.10.02 |
| 申请号 |
CA20002396534 |
申请日期 |
2000.12.18 |
| 申请人 |
ESBATECH AG |
发明人 |
AUF DER MAUR, ADRIAN;BARBERIS, ALCIDE;ESCHER, DOMINIK |
| 分类号 |
C07K16/00;C12N15/09;A61K39/395;C07K14/00;C07K16/14;C07K19/00;C12N7/01;C12N15/10;C12N15/13;C12N15/74;C12P21/02;C12Q1/02;G01N33/577 |
主分类号 |
C07K16/00 |
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