发明名称 METHOD FOR PRODUCING HIGH-PURITY PRASUGREL HYDROCHLORIDE
摘要 An object of the present invention is to provide prasugrel hydrochloride with a reduced content of CATP, and the like. (see multi-step process above) In the formulae, R represents a protecting group for a hydroxyl group. A method for producing prasugrel hydrochloride represented by the above formula is provided, characterized by comprising, in step (i), controlling, at low values, the temperature during the addition, optionally dropwise, of a chlorinating agent and the reaction temperature after the addition, optionally dropwise, of the chlorinating agent.
申请公布号 CA2679925(C) 申请公布日期 2012.10.02
申请号 CA20082679925 申请日期 2008.02.29
申请人 DAIICHI SANKYO COMPANY, LIMITED;UBE INDUSTRIES, LTD. 发明人 MIYATA, HIROYUKI;WADA, YUKINORI;YOKOTA, NAOYUKI
分类号 C07D495/04;A61K31/4365;A61P7/02 主分类号 C07D495/04
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