发明名称 |
Small molecule inhibition of intracellular transport |
摘要 |
The present disclosure characterizes the activity of Golgicide A (GCA), as a potent, specific and reversible small molecule inhibitor of Golgi BFA resistance factor 1 (GBF1) function. A mutant GBF1 gene that is resistant to GCA is also described. Methods of using GCA and the GCA-resistant GBF1 gene are described including methods for modulating GBF1 activity for research and therapeutic purposes. Also described are compositions incorporating a GCA-resistant GBF1. |
申请公布号 |
US8278321(B2) |
申请公布日期 |
2012.10.02 |
申请号 |
US20090645094 |
申请日期 |
2009.12.22 |
申请人 |
HASLAM DAVID B.;WASHINGTON UNIVERSITY |
发明人 |
HASLAM DAVID B. |
分类号 |
A01N43/42;A01N43/40;A61K31/44;A61K31/445;C07D211/06;C07D221/06;C07D221/22 |
主分类号 |
A01N43/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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