发明名称 |
Use of trifunctional bispecific and trispecific antibodies for the treatment of malignant ascites |
摘要 |
The invention describes the use of a pharmaceutical preparation containing a trifunctional bispecific and/or trispecific having the following properties: a) binding to a T cell; b) binding to at least an antigen on a tumor cell associated with malignant ascites and/or pleural effusion; c) binding, by its Fc portion (in the case of bispecific antibodies) or by a third specificity (in the case of trispecific antibodies), to Fc receptor-positive cells for the destruction of the tumor cells in the treatment of malignant ascites and/or pleural effusion. |
申请公布号 |
US8277806(B2) |
申请公布日期 |
2012.10.02 |
申请号 |
US20030378218 |
申请日期 |
2003.03.03 |
申请人 |
LINDHOFER HORST;TRION PHARMA GMBH |
发明人 |
LINDHOFER HORST |
分类号 |
A61K39/395;A61K39/00;A61P35/00;C07K16/28;C07K16/30;C07K16/32 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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